TABLE 4

Sulfation of raloxifene and 4-hydroxytamoxifen by human proliferative and secretory endometrial cytosols

Cytosols were prepared from endometrial Pipelle biopsies of four patients collected during the proliferative (Pro) and secretory (Sec) phases of the menstrual cycle (Zhang et al., 1998). Cytosols were assayed in triplicate for sulfation activity with 5 μM raloxifene or 4-OHT as substrate, as described under Materials and Methods. The values represent means ± standard deviation of four reactions.