A correlation (r value) between the rate of thioridazine metabolism and the velocity of P450-specific reactions in human liver microsomes
Each pair of data was compared by a simple linear regression analysis using the statistical program Prism 2.01 (GraphPad Software, Inc.). Statistical significance was indicated with ** p < 0.01 and * p < 0.05; N.S. (p > 0.05) is statistically not significant.
Phenacetin O-Deethylation (CYP1A2) | Coumarin 7-Hydroxylation (CYP2A6) | S-Mephenytoin N-Demethylation (CYP2B6) | Diclofenac 4′-Hydroxylation (CYP2C9) | S-Mephenytoin 4′-Hydroxylation (CYP2C19) | Bufuralol 1′-Hydroxylation (CYP2D6) | Chlorzoxazone 6-Hydroxylation (CYP2E1) | Testosterone 6β-Hydroxylation (CYP3A4) | |
|---|---|---|---|---|---|---|---|---|
| Thioridazine mono-2-sulfoxidation | -0.21N.S. | 0.58N.S. | -0.50N.S. | 0.20N.S. | -0.52N.S. | 0.74* | 0.47N.S. | 0.71* |
| Thioridazine di-2-sulfoxidation | -0.37N.S. | -0.06N.S. | -0.90N.S. | 0.05N.S. | -0.25N.S. | 0.73* | 0.18N.S. | -0.57N.S. |
| Thioridazine 5-sulfoxidation | 0.77* | 0.08N.S. | 0.09N.S. | -0.01N.S. | 0.24N.S. | -0.37N.S. | 0.08N.S. | 0.71* |
| Thioridazine N-demethylation |
0.72*
| 0.35N.S. | 0.70N.S. | -0.01N.S. | 0.16N.S. | 0.25N.S. | 0.16N.S. |
0.84**
|