TABLE 2

Pharmacokinetic parameters for ITZ stereoisomer pairs in subject E after a single dose administration (day 1) of a 100-mg oral solution of itraconazole and after multiple dose administration (100 mg/day) for 7 days


Parameter

Day 1

Day 7
(2R,4S)-ITZ
(2S,4R)-ITZ
(2R,4S)-ITZ
(2S,4R)-ITZ
CL/F (l/h) 209 29 34 13
AUCa (h · nmol/l) 339 2460 2090 5640
t1/2 (h) 9.0 19 10 25
Cmax (nmol/l)
99
302
538
579
  • a For day 1, AUC0-inf and for day 7, AUC0--24.