TABLE 2

The unbound fraction (fu) and in vivo clearances of used compounds




fu

CL

Reference
ml/min/kg
Warfarin 0.11 0.18 Shibata et al., 2000
7-EC 0.22 40 Carlile et al., 1998
7-HC 0.10 97.4 Ritschel et al., 1992
Testosterone 0.40 62 Pardridge, 1986; De Kanter et al., 2004
Midazolam 0.04 79 Kotegawa et al., 2002
Quinidine 0.325 33.8 Sawada et al., 1985
Haloperidol
0.08
78
Lombardo et al., 2002; Cheng and Paalzow, 1992