TABLE 1

Kinetic parameters for the formation of metabolites from [14C]lonafarnib with pooled human liver microsomes


Kinetic Parametersa

M1

M2
Km (μM) 24.9 ± 3.63b 44.03 ± 10.30
Vmax (pmol/nmol P450/min) 262 ± 0.01 133 ± 0.01
Vmax/Km (μl/nmol P450/min)c
10.52
3.02
  • a Kinetic parameters determined by GraFit 4.0 program.

  • b Standard error.

  • c Intrinsic clearance.