Pharmacokinetic parameters governing CDF disposition in single-pass perfused livers from wild-type, Abcg2-/-, and Abcc2-/- mice were estimated using nonlinear regression analysis with the compartmental model shown in Fig. 5
Wild-Type | Abcg2-/- | Abcc2-/- | |
|---|---|---|---|
| Clup (ml/min) | 4.0 ± 0.7 | 4.4 ± 0.2 | 4.2 ± 0.5 |
| kbile (min-1) | 0.039 ± 0.011 | 0.061 ± 0.005* | N.C. |
| kperfusate (min-1) | 0.030 ± 0.011 | 0.031 ± 0.004 | 0.12 ± 0.02* |
Data represent the mean ± S.D. of three to six experiments. N.C., not calculated.
↵* p < 0.05 compared with wild-type mice.