Pharmakocinetic parameters after intravenous administration of [14C]olmesartan to SDR and EHBR at a dose of 1 mg Eq of [14C]olmesartan/kg
Strain | AUC0-2 h | Cumulative Biliary Excretion (0-2 h) | CLbilea |
|---|---|---|---|
| μg Eq · h/ml | % of dose | ml/min/kg | |
| SDR | 5.58 ± 1.48 | 68.12 ± 11.81 | 2.22 ± 0.94 |
| EHBR | 8.34 ± 0.86 | 11.45 ± 3.73 | 0.24 ± 0.09 |
SDR, Sprague-Dawley rats.
↵ a CLbile was calculated according to eq. 3.