TABLE 2

Pharmakocinetic parameters after intravenous administration of [14C]olmesartan to SDR and EHBR at a dose of 1 mg Eq of [14C]olmesartan/kg


Strain

AUC0-2 h

Cumulative Biliary Excretion (0-2 h)

CLbilea
μg Eq · h/ml % of dose ml/min/kg
SDR 5.58 ± 1.48 68.12 ± 11.81 2.22 ± 0.94
EHBR
8.34 ± 0.86
11.45 ± 3.73
0.24 ± 0.09
  • SDR, Sprague-Dawley rats.

  • a CLbile was calculated according to eq. 3.