TABLE 3

Specific P450 contents (picomoles per milligram microsomal protein) in human small intestinal microsomes (HIM)

P450
1A1
2A6
2B6
2C9
2C19
2D6
2E1
2J2
3A4
3A5
Mean (individuals) 5.6 BLD BLD 8.4 1.0 0.5 BLD 0.9 43 16
n 3 31 31 31 31 29 31 31 31 11
Range 3.6-7.7 2.9-27 <0.6-3.9 <0.2-1.4 <0.2-3.1 8.8-150 4.9-25
Mean ± S.D.a (pooled HIM)b BLD BLD BLD 11 ± 0.5 2.1 ± 0.1 0.7 ± 0.01 BLD 1.0 ± 0.1 58 ± 1.0 16 ± 0.3
LOD
1.5
2.0
1.3
2.0
0.6
0.2
0.2
0.2
8
4

  • BLD, below limit of detection; LOD, limit of detection (picomoles per milligram).

  • ↵ a Values denote the mean ± S.D. of triplicate measurements.

  • ↵ b The pooled sample consisted of 31 (for P450s 1A1, 2A6, 2B6, 2C9, 2C19, 2D6, 2E1, and 3A4) or 11 (for CYP3A5) individual preparations.