Mean (±S.E.M.) values of the effective jejunal permeability (Peff) and fraction absorbed of the dose available (fabs) for fexofenadine, verapamil, and antipyrine together with other perfusion parameters for the group that was administered fexofenadine alone (G1; 120 mg/l, total dose 24 mg; n = 6) and for those who received fexofenadine together with verapamil (G2; 175 mg/l, total dose 35 mg; n = 7, G3; 1000 mg/l, total dose 200 mg; n = 7)
Control (G1) | Treatment (G2) | Treatment (G3) | |
|---|---|---|---|
| Fexofenadine | |||
| Peff (10-4 cm/s) | 0.02 ± 0.01 | 0.10 ± 0.02* | 0.04 ± 0.01 |
| fabs (%) | 1 ± 0 | 3 ± 1* | 1 ± 0 |
| Verapamil | |||
| Peff (10-4 cm/s) | 0.64 ± 0.14 | 0.35 ± 0.07 | |
| fabs (%) | 17 ± 3 | 9 ± 2 | |
| Antipyrine | |||
| Peff (10-4 cm/s) | 0.49 ± 0.09 | 0.83 ± 0.17 | 0.50 ± 0.13 |
| fabs (%) | 14 ± 2 | 20 ± 4 | 12 ± 3 |
| PEG 4000 rec (%) | 85 ± 7 | 96 ± 2 | 99 ± 6 |
| NWF (ml/h · cm) | 0.66 ± 0.31 | 0.20 ± 0.09 | 0.62 ± 0.28 |
| Qout (ml/min) | 1.70 ± 0.11 | 1.84 ± 0.06 | 2.32 ± 0.20 |
| pH | 6.67 ± 0.05 | 6.63 ± 0.02 | 6.51 ± 0.01 |
| Osmolality (mOsm/kg) | 293 ± 10 | 287 ± 8 | 260 ± 5 |
rec, recovery.
↵* statistically different from control (P < 0.05).