Study Level Parameters Estimated  
Parameter  Population Estimate  SEE  Interstudy Variability  SEE  
K_{a} (h^{1})  1.10  (16.3)  33%  (67.2)  
V_{max} (mg/h)  41.1  (6.01)  49%  (75.0)  
K_{m} (mg/l)  0.810  (12.5)  —  —  
K_{eff} (mg/l)  300.1  (12.1)  —  —  
V_{4} (liters)  32.1  (11.4)  —  —  
V_{5} (liters)  19.6  (38.0)  —  —  
Q_{4} (l/h)  2.39  (7.82)  —  —  
Residual error (proportional)  0.10  (25.0) 

 
Parameters Fixed for the Enzyme Site Compartment^{a}  
Parameter  Typical Value (fixed)  Interstudy Variability  
T_{max} (mg/h)  1  —^{a}  
K_{2e} (h^{1})  1  —^{a}  
Q_{h} (l/h)  48  —^{a}  
V_{2} and V_{e} (liters)  0.825  —^{a} 
K_{a}, first order absorption rate constant; V_{max}, maximum rate of elimination; K_{m}, Michaelis Menten constant for saturable elimination kinetics; V_{4}, central volume of distribution; V_{5}, peripheral volume of distribution; Q_{4}, intercompartmental flow constant; T_{max}, maximum rate of efflux; K_{eff}, saturable efflux constant; K_{2e}, firstorder rate constant for uptake into enzyme site; Q_{h}, plasma flow between hepatic and central compartments; V_{2}, hepatic volume of distribution in equilibrium with plasma; V_{e}, enzyme site volume of distribution within the hepatic tissue; SEE, standard error of the estimate in %; , not estimated
↵ a Assumed typical value for simulations without variability.