Kinetic parameters of the transcellular transport of valsartan in OATP1B1/MRP2 double transfectant
Data shown in Fig. 6 were used to determine these parameters calculated by nonlinear regression analysis as described under Materials and Methods. Each parameter represents the mean ± computer-calculated S.D.
Km | Vmax | Pdif | |
|---|---|---|---|
| μM | pmol/min/mg protein | ml/min/mg protein | |
| Transcellular transport | 27.5 ± 4.1 | 164 ± 24 | 0.937 ± 0.123 |
|
PS
apical
| 99.0 ± 51.1 | 461 ± 275 | 0.120 ± 0.610 |