Summary for the pharmacokinetic parameters of valsartan in SD rats and EHBRs
Pharmacokinetic parameters are expressed as mean ± S.E. (n = 3).
AUC0-∞ | V1 | CLp | Liver Concentration | CLbile | |
---|---|---|---|---|---|
μg · min/ml | ml/kg | ml/min/kg | ng/g liver | ml/min/kg | |
SD rat | 58.9 ± 9.1 | 76.3 ± 7.0 | 17.8 ± 2.5 | 1.41 ± 0.22 | 12.5 ± 1.0 |
EHBR | 991 ± 32** | 49.0 ± 0.8* | 1.01 ± 0.03** | 3.45 ± 0.19** | 0.283 ± 0.010** |
↵* P < 0.05, ** P < 0.01.