TABLE 1

Average pharmacokinetic parameters determined in the present investigation following intravenous administration in the male cynomolgus monkey or beagle dog (n = 2 animals)


Compound

Species

CL

Vd

MRT
ml/min/kg l/kg min
Haloperidol Dog 33.0 37.0 1128
Mifepristone Dog 15.7 10.5 692
Amiodarone Monkey 10.7 5.11 469
Biperiden Monkey 21.9 3.61 179
Chlorpromazine Monkey 24.6 8.03 340
Diltiazem Monkey 34.5 3.52 102
Felodipine Monkey 15.6 2.19 140
Methadone Monkey 29.4 8.21 266
Vinorelbine Monkey 23.6 11.4 474
Nifedipine Monkey 10.0 0.534 52.7
Propafenone Monkey 44.1 8.24 197
Remoxipride Monkey 11.8 1.13 91
Verapamila
Monkey
37.1
4.54
122
  • a Value represents n = 1 datum only, due to technical difficulties on the study day.