TABLE 2

Accuracy of human clearance predictions from preclinical species using various methodologies


Method

Qualitative [Class] Number Correct (%)

Quantitative [2-fold] Number Correct (%)

MAE (%)
ml/min/kg
Rat LBF 7 (33.3) 11 (52.4) 8.38 (113)
Dog LBF 7 (33.3) 6 (28.6) 11.8 (159)
Monkey LBF 8 (38.1) 10 (47.6) 6.08 (81.9)
Three-species allometry 8 (38.1) 7 (33.3) 11.9 (160)
Three-species allometry with RE
9 (42.9)
10 (47.6)
6.08 (81.9)
  • RE, rule of exponent correction.