TABLE 5

Accuracy of human Vd predictions from preclinical species using various methodologies


Method

Qualitative (Class) Number (%) Correct

Quantitative (2-fold) Number (%) Correct

MAE (%)
ml/min/kg
Rat 13 (61.9) 13 (61.9) 5.63 (54.8)
Dog 17 (81.0) 13 (61.9) 7.76 (75.7)
Monkey 14 (66.7) 12 (57.1) 9.62 (93.8)
Three-species allometry
13 (61.9)
13 (61.9)
9.88 (96.4)