TABLE 2

Summary of derived pharmacokinetic parameters of ATV in rats (n = 5) after a single oral dose (10 mg/kg) or intravenous dose (2 mg/kg) of ATV with and without RIF given as a bolus intravenous dose (20 mg/kg)

Data are mean values ± S.D. (n = 5); the level of significance was set at p < 0.05.

	CL_iv^a	(f_u × CL_int)^a	V_ss ^a	AUC_M/AUC_P^b
	CL_iv^a	(f_u × CL_int)^a	V_ss ^a			i.v.	Oral
	ml/min/kg			l/kg
ATV alone	32.3 ± 7.1	88.0 ± 42.6	10.2 ± 3.4	0.033 ± 0.006	0.22 ± 0.12^†
with RIF	23.3 ± 3.9*	41.4 ± 11.6*	7.5 ± 5.1	0.11 ± 0.04**	0.20 ± 0.09^†

↵ a Blood values following intravenous dosing.
↵ b AUC_{0-2 h} ratio of ATV metabolites (sum of 2-OH ATV and 4-OH ATV) to ATV.
↵* p < 0.05; ** p < 0.01 compared with values for the same dosing route in the absence of RIF.
↵† Significantly different from comparable intravenous ratio (p < 0.01).