TABLE 3

Measures of ATV bioavailability and calculated hepatic and gut metabolic extraction based on eqs. 1 to 4

Data are mean values ± S.D. (n = 5).

ATV
F
ERH
FH
(Fabs × FG)
Alone 0.052 ± 0.020 0.58 ± 0.13 0.42 ± 0.13 0.14 ± 0.08
With RIF
0.14 ± 0.03***
0.42 ± 0.07*
0.58 ± 0.07*
0.24 ± 0.04*

  • ↵* p < 0.05; *** p < 0.001 compared with ATV alone.