TABLE 8

Distribution of UGT1A3 alleles in a Chinese Han population

UGT1A3 Alleles
Nucleotide Change
Amino Acid Change
Frequency in a Chinese Han Population (n = 250)
Frequency in Japanese (n = 200)a
Frequency in German-Caucasians (n = 162)b
UGT1A3*1 0.676 0.610 0.350c
UGT1A3*2a T31C/G81A/T140C W11R/E27E/V47A 0.012 —d 0.580c
UGT1A3*2b T31C/G81A/T140C/A477G W11R/E27E/V47A/A159A 0.092 0.125 —
UGT1A3*3a T31C/G81A W11R/E27E 0.048 — 0.070
UGT1A3*3b T31C/G81A/A477G W11R/E27E/A159A 0.072 0.100 —
UGT1A3*4 C133T R45W 0.056 0.110c —
UGT1A3*5
A17G/T31C/G81A/A477G
Q6R/W11R/E27E/A159A
0.044
0.055
—

  • ↵ a Frequencies in Japanese were published by Iwai et al. (2004).

  • ↵ b Frequencies in German-Caucasians were published by Ehmer et al. (2004).

  • ↵ c Statistically different (p < 0.05) versus frequency in a Chinese Han population, two-sided Student's t test.

  • ↵ d —, unpublished data.