Pharmacokinetic parameters for FTY720 in blood after single i.v. doses in rats calculated by compartmental analysis
Parameter | Dose | Mean | S.D. | ||||
|---|---|---|---|---|---|---|---|
| 0.3 mg/kg | 2 mg/kg | 4 mg/kg | |||||
| t1/2 (h) | 18.5 | 30.7 | 20.9 | 23.4 | 6.43 | ||
| CL (l/h/kg) | 0.341 | 0.462 | 0.687 | 0.497 | 0.176 | ||
| Vss (l/kg) | 5.61 | 16.2 | 19.4 | 13.7 | 7.22 | ||