Human | Rat | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Compound | Hepatocytes | Microsomes (n = 3) | Hepatocytes | Microsomes (n = 3) | ||||||
Fresh (n = 4) | Cryopreserved (n = 7) | Fresh (n = 3) | Cryopreserved (n = 5) | |||||||
l/h/kg | l/h/kg | |||||||||
7-EC | 1.80 | 1.57 | 7.34 | 2.50 | 2.69 | 16.8 | ||||
Phenacetin | 0.74 | 0.33 | 1.15 | 0.49 | 0.58 | 6.38 | ||||
Propranolol | 0.37 | 0.63 | 1.72 | 2.73 | 3.20 | 79.0 | ||||
Midazolam | 0.69 | 0.98 | 22.4 | 2.46 | 2.74 | 113 |