Selectivity of chemical inhibitors against probe substrates
Substrate (1 μM) | Effect of Inhibitor (Mean % Inhibition) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 10 μM Furafylline | 10 μM Sulfaphenazole | 3 μM Benzylnirvanol | 1 μM Quinidine | 1 μM Ketoconazole | |||||
| Phenacetin | >81.3 | 15.2 | 20.5 | 1.4 | 17.0 | ||||
| Diclofenac | 20.6 | >92.9 | 7.5 | 0 | 12.9 | ||||
| S-Mephenytoin | 6.1 | 5.8 | 98.6 | 7.0 | 5.0 | ||||
| Dextromethorphan | 17.4 | 5.7 | 7.4 | 90.4 | 15.6 | ||||
| Midazolam | 0 | 0 | 4.3 | 3.3 |
87.4
| ||||