Form Dosed | Form Measured | Matrix | Time | KO | WT | ||||
---|---|---|---|---|---|---|---|---|---|
Conc. | Tissue/Plasma Ratio | Conc. | Tissue/Plasma Ratio | ||||||
h | ng/ml | ng/ml | |||||||
Lactone | Lactone | Plasma | 0.5 | 12 ± 3 | 13 ± 3 | ||||
Acid | Plasma | 0.5 | 23 ± 4 | 28 ± 6 | |||||
Acid | Acid | Plasma | 0.5 | 593 ± 248 | 543 ± 79 | ||||
Plasma | 1.5 | 112 ± 35 | 145 ± 30 | ||||||
Plasma | 3 | 37 ± 16 | 91 ± 27 | ||||||
Liver | 0.5 | 1113 ± 169 | 2.1 ± 0.9 | 915 ± 247 | 1.7 ± 0.3 | ||||
Liver | 1.5 | 360 ± 168 | 3.5 ± 1.8 | 340 ± 20 | 2.4 ± 0.6 | ||||
Liver | 3 | 119 ± 64 | 3.2 ± 0.5 | 145 ± 64 | 1.6 ± 0.3 | ||||
|
| Brain | 0.5 | 39 ± 5 | 0.074 ± 0.027 | 26 ± 1 | 0.044 ± 0.003 |