TABLE 4

Statistics for the predicted human pharmacokinetic parameters obtained using method Vd1 and method CL1

See Materials and Methods for more details on prediction of each parameter using method Vd1 and/or method CL1.


Parameter

n

afe

rmse

Percentage within 2-fold Error

Percentage within 3-fold Error
Vss (l) 19 2.10 604 31.6 52.6
CL (l/h) 19 2.41 36.3 52.6 68.4
CLR (l/h) 4 1.09 5.41 100 100
In vivo t½ (h) 26 5.40 903 26.9 38.5
Vd/F (liters) 23 1.38 9.33E + 03 21.7 39.1
AUC (ng · h/ml) 23 5.09 7.91E + 04 34.8 43.5
Cmax (ng/ml) 23 1.39 2.94E + 03 65.2 69.6
F (%)
16
1.60
31.0
62.5a

  • a Percentage within 1.5-fold error.