TABLE 5

Statistics for the predicted human pharmacokinetic parameters obtained using method Vd2 and method CL2

See Materials and Methods for more details on prediction of each parameter using method Vd2 and/or method CL2.


Parameter

n

afe

rmse

Percentage within 2-fold Error

Percentage within 3-fold Error
Vss (liters) 19 1.14 207 84.2 94.7
CL (l/h) 19 1.10 31.3 73.7 89.5
CLR (l/h) 4 1.09 5.41 100 100
In vivo t½ (h) 26 1.49 8.72 69.2 88.5
Vd/F (liters) 23 1.32 2.10E + 03 69.6 82.6
AUC (ng · h/ml) 23 1.06 6.45E + 03 73.9 87.0
Cmax (ng/ml) 23 1.31 2.01E + 03 65.2 91.3
F (%)
16
1.06
15.0
81.3a

  • a Percentage within 1.5-fold error