Effect of plasma protein binding and source of rat Ptp data on prediction accuracy of human Vss using method Vd2
For more details on method Vd2, see Materials and Methods.
Parameter | n | fup Correctiona | Source of Rat Ptp Data | afe | rmse | Percentage within 2-fold Error | Percentage within 3-fold Error |
|---|---|---|---|---|---|---|---|
| Vss (liters) | 19 | Yes | Predicted + Experimentalb | 1.14 | 207 | 84.2 | 94.7 |
| Vss (liters) | 19 | No | Predicted + Experimentalb | 1.54 | 361 | 52.6 | 68.4 |
| Vss (liters) | 19 | Yes | Predictedc | 1.44 | 377 | 47.4 | 78.9 |
| Vss (liters) | 19 | No | Predictedc | 1.89 | 600 | 42.1 | 78.9 |
↵ a “Yes” refers to the assumption that human unbound Ptp is equal to rat unbound Ptp; “No” refers to the assumption that human Ptp is equal to rat Ptp.
↵ b In instances where the experimental in vivo rat Ptp was not available, the value for that particular tissue was predicted as described for method Vd2. All experimentally determined in vivo rat Ptp values are given in Table 2.
↵ c Only predicted rat Ptp values were used for all tissue compartments. All values were predicted as described for method Vd2.