TABLE 8

Statistics for the predicted human plasma concentrations after oral dosing

For details on prediction of oral plasma concentrations using method Vd1/CL1 and method Vd2/CL2, see Materials and Methods.

Approach
n a
afe
rmse
Percentage within 1.5-fold Error
Percentage within 2-fold Error
Percentage within 3-fold Error
Method Vd1/CL1 261 2.29 1.57 25.7 36.5 50.9
Method Vd2/CL2
261
1.03
1.20
43.4
60.0
74.8

  • ↵ a The total pool (n = 261) of mean plasma concentrations (ug/ml) for all compounds of TABLE 2 after oral dosing.