TABLE 1

Pharmacokinetic parameters of celiprolol in rat plasma in control, coadministered, and treatment groups following a p.o. dose of 30 mg/kg

Data are presented as mean ± S.E.M. (n = 5).

Parameter
Control
Coadministered
Treatment
Cmax (ng/ml) 492.65 ± 33.21 458.21 ± 78.05 960.14 ± 93.39**
tmax (min) 120.0 ± 0.0 108.0 ± 6.6 120.0 ± 0.0
AUC0-8 (ng/ml × h) 2140.04 ± 187.87 2347.63 ± 287.83 3440.26 ± 210.45*
Total AUCa (ng/ml × h) 3570.91 ± 106.26 4114.26 ± 103.22 4582.18 ± 382.65*
CLoral (ml/h)
2.36 ± 0.07
2.02 ± 0.06
1.85 ± 0.15**

  • ↵* p ≤ 0.05 significant difference compared with control; ** p ≤ 0.01 significant difference compared with control.

  • ↵ a Total AUC, area under concentration curve extrapolated to infinity.