Summary and comparison of the tissue distribution of human, rat, and mouse UGTs in liver, stomach, small intestine, colon, and kidney
Genes listed for human are based upon presence in tissue. Genes listed for rodents are based on high expression from bDNA data.
Tissue | UGT Family | Humana | Rata | Mouse |
|---|---|---|---|---|
| Liver | 1A | 1, 3, 4, 6, 9 | 1, 5, 8 | 1, 5, 6, 9 |
| 2A/2B | B4, 7, 10, 11, 15, 17 | B1, 2, 3, 6, 12 | a3; b1, 5, 34, 35, 36, 37, 38 | |
| 3A | 1, 2 | |||
| Stomach | 1A | 3, 6, 7, 10 | 1 | |
| 2B | 10 | 8 | 34, 35 | |
| Small intestine | 1A | 1, 3, 4, 5, 6, 10 | 1, 2, 3, 6, 7 | 7 |
| 2A/2B | A2; B4, 7, 10, 15, 17 | 8 | b34, 35 | |
| Large intestine | 1A | 1, 3, 4, 6, 8, 9, 10 | 1, 3, 6, 7 | 6, 7 |
| 2B | 7, 10, 15 | 34, 35 | ||
| Kidney | 1A | 9 | 1, 6, 8 | 2, 7, 10 |
| 2B | 4, 7, 10, 11, 15, 17 | 12 | 5, 35 | |
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3A
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| 1, 2 |
↵ a References for Human values: Beaulieu et al., 1996, 1998; Levesque et al., 1997, 1999; Strassburg et al., 2000; Tukey and Strassburg, 2001; Turgeon et al., 2001; Basu et al., 2004. References for Rat: Shelby et al., 2003.