Pharmacokinetic parameters of olmesartan during constant infusion into wild-type and Mrp4 knockout mice
Data represent the mean ± S.E. [n = 7 (wild-type), 6 (Mrp4-knockout mice)].
Css,p | CLtot,p | CLrenal,p | fp · GFR | Kp,kidney | |
|---|---|---|---|---|---|
| μM | ml/min/kg | ml/min/kg | ml/min/kg | ||
| Wild-type | 1.43 ± 0.09 | 7.22 ± 0.58 | 0.384 ± 0.092 | 1.02 ± 0.12 | 0.603 ± 0.151 |
| Knockout | 1.58 ± 0.25 | 7.32 ± 1.32 | 0.280 ± 0.082 | 0.857 ± 0.126 | 0.582 ± 0.144 |
Css,p, the mean value of the plasma concentration at 60, 90, and 120 min; CLtot,p, total plasma clearance; CLrenal,p, renal clearance with respect to the circulating plasma concentration; fp · GFR, glomerular filtration rate multiplied with plasma protein unbound fraction; Kp,kidney, Kp value obtained by dividing the kidney concentration by Css,p (at 120 min).