Formation of [14C]muraglitazar glucuronide in human cDNA-expressed UGT enzymes and human liver microsomes (HLM A)
Metabolite | Enzyme | Km a | Vmax a |
|---|---|---|---|
| μM | pmol/min/mg protein | ||
| M13 | UGT1A1 | 3.8 | 309.9 |
| UGT1A3 | 3.7 | 668.0 | |
| UGT1A9 | 2.1 | 80.0 | |
|
| HLM | 3.6 | 583.5 |
↵ a Kinetic values were estimated by Michaelis-Menten kinetic analysis.