Pharmacokinetic parameters of TGZS in the in vivo biliary excretion study
The data are represented by mean values ± S.E. of four mice.
Animal | CLtotal | CLbile, plasma | CLbile, liver | Fraction of Biliary Excretion |
|---|---|---|---|---|
| ml/min/kg | % | |||
| Wild-type | 10.6 ± 1.4 | 10.9 ± 1.9 | 0.148 ± 0.017 | 102 ± 6 |
| Bcrp (-/-) | 13.3 ± 1.4 | 4.15 ± 0.86* | 0.0424 ± 0.0115** | 32.6 ± 7.9*** |
↵* P < 0.05, ** P < 0.01, and *** P < 0.001 statistical significance between wild-type and Bcrp (-/-) mice analyzed by two-tailed Student's t test.