Km | Vmax | Vmax/Km | |
---|---|---|---|
mM | pmol/min/pmol P450 | nl/min/pmol P450 | |
8-Hydroxylation (1,3-DMU formation) | |||
CYP1A1 | 3.9 ± 0.1 | 5.1 ± 0.2 | 1.3 ± 0.1 |
CYP1A2 | 0.6 ± 0.0 | 24.4 ± 2.5 | 40.0 ± 4.0 |
CYP2A6 | 8.7 ± 0.4a,b | 7.4 ± 0.3a,b | 0.9 ± 0.0a,b |
CYP2A13 | 2.5 ± 0.1a,b | 10.3 ± 0.4a,b | 4.1 ± 0.2a,b |
3-Demethylation (1-MX formation) | |||
CYP1A1 | 11.1 ± 1.5 | 1.7 ± 0.2 | 0.2 ± 0.0 |
CYP1A2 | 0.6 ± 0.1 | 1.0 ± 0.2 | 1.8 ± 0.3 |
CYP2A6 | N.D. | N.D. | N.D. |
CYP2A13 | 1.4 ± 0.2a,b | 0.2 ± 0.0a,b | 0.2 ± 0.0b |
1-Demethylation (3-MX formation) | |||
CYP1A1 | N.D. | N.D. | N.D. |
CYP1A2 | 0.6 ± 0.1 | 1.1 ± 0.2 | 1.8 ± 0.3 |
CYP2A6 | N.D. | N.D. | N.D. |
CYP2A13 | N.D. | N.D. | N.D. |