In vivo human clearance values for n = 9 compounds in this study and the key parameters for prediction
References for plasma clearance data are available at www.capkr.man.ac.uk.
Compound | Observed Plasma Clearance | Number of in Vivo Studies | Number of Individuals | RB | fup |
|---|---|---|---|---|---|
| ml/min/kg | |||||
| S-Warfarin | 0.06 | 1 | 10 | 0.55 | 0.01 |
| Tolbutamide | 0.24 | 6 | 35 | 0.75 | 0.05 |
| Diclofenac | 3.8 | 1 | 7 | 0.55 | 0.01 |
| Quinidine | 5.2 | 4 | 30 | 0.87 | 0.13 |
| Nifedipine | 8.1 | 9 | 54 | 0.59a | 0.04 |
| Bufuralol | 8.8 | 1 | 7 | 0.80 | 0.19 |
| Mephenytoin | 53b | 3 | 35 | 0.84 | 0.60 |
| Dextromethorphan | 415b | 5 | 72 | 1.76a | 0.50a |
| Terfenadine | 1300b | 5 | 69 | 1 | 0.03 |