Inhibitor | Microsome | Inhibition Type | Ki | ||||
---|---|---|---|---|---|---|---|
Human | Monkey | Human | Monkey | ||||
μm | |||||||
KTZ | Liver | Noncompetitive | Noncompetitive | 0.032 | 0.025 | ||
Intestinal | Noncompetitive | Noncompetitive | 0.044 | 0.015 | |||
ITZ | Liver | Competitive | Noncompetitive | 0.13 | 0.096 | ||
Intestinal | Competitive | Noncompetitive | 0.099 | 0.062 | |||
FLZ | Liver | Noncompetitive | Mixed-type | 21 | 14 | ||
| Intestinal | Noncompetitive | Mixed-type | 35 | 47 |