TABLE 3
Estimated IC
50
(μM) of typical inhibitors on BVM (25 μM) UGT activity in human liver microsomes
Inhibitor
IC
50
Mono-BVMG (I)
mono-BVMG (II)
μ
M
Bilirubin
>500
>500
Etoposide
>500
>500
Imipramine
432
>500
Trifluoperazine
232
246
AZT
>500
>500
Diclofenac
292
>500