TABLE 1

Noncompartmental plasma MPA and MPAG pharmacokinetic parameters for male and female SD rats treated with 50 mg MPA equivalents/kg/day for 2 days

Data are mean ± S.E. from n = 5 rats. Values for MPAG AUC, and Cmax are expressed in MPA equivalents.

Parameter
MPA
MPAG
Male
Female
Male
Female
AUCa (μg · min/ml) 3940 ± 787 5530 ± 692 322 ± 42b 252 ± 29
Cmax (μg/ml) 21 ± 5 26 ± 3 0.7 ± 0.3 0.5 ± 0.1
tmax (min)
30 ± 0
30 ± 0
121 ± 81
59 ± 39

  • ↵ a AUC from zero to the last sampling time, 540 min.

  • ↵ b p < 0.05.