Pharmacokinetic parameters of sitagliptin in rats and dogs after intravenous administration
Male Sprague-Dawley rats and beagle dogs were dosed with a solution of the phosphate salt in saline. Mean ± standard deviation values are listed (n = 3 or 4). Dose is expressed in mg of free base/kg body weight.
Species | Dose | AUC0-∞ | CLp | Vdss | t1/2 |
|---|---|---|---|---|---|
| mg/kg | μM · h | ml/min/kg | l/kg | h | |
| Rat | 0.5 | 0.459 ± 0.100 | 46 ± 8.2 | 8.8 ± 3.4 | 1.7 ± 0.3 |
| 2 | 2.05 ± 0.051 | 40 ± 0.96 | 8.1 ± 2.0 | 1.9 ± 0.3 | |
| 5 | 4.28 ± 0.318 | 48 ± 3.6 | 7.4 ± 1.2 | 1.8 ± 0.2 | |
| Dog | 0.5 | 2.20 ± 0.36 | 9.3 ± 1.3 | 3.2 ± 0.1 | 4.0 ± 0.4 |
|
| 1.5 | 7.11 ± 1.35 | 8.8 ± 1.5 | 3.4 ± 0.5 | 4.2 ± 0.2 |