Dose recovery (percentage) in urine and feces after single dose administration of [14C]sitagliptin to rats
Excreta were collected for 3 days from BDC rats and 5 days from intact rats and BDC dogs; values are mean ± standard deviation (n = 3).
Species | Dose | Recovery of Radioactivity (% Dose) | ||||||
|---|---|---|---|---|---|---|---|---|
| Urine | Bile | Feces | Total | |||||
| Rat | 2 mg/kg i.v. | 54 ± 5.8 | N.D. | 40 ± 3.2 | 94 ± 9.0 | |||
| 5 mg/kg p.o. | 37 ± 2.6 | N.D. | 59 ± 2.5 | 96 ± 5.1 | ||||
| BDC Rat | 2 mg/kg i.v. | 55 ± 1.4 | 21 ± 1.2 | N.D. | N.D. | |||
| 5 mg/kg p.o. | 54 ± 7.3 | 20 ± 6.7 | N.D. | N.D. | ||||
| 20 mg/kg p.o. | 53 ± 7.7 | 29 ± 5.8 | N.D. | N.D. | ||||
| BDC Dog | 0.5 mg/kg i.v. | 75.0 ± 4.5 | 8.1 ± 4.2 | 9.3 ± 2.0 | 95 ± 4.9a | |||
|
| 2 mg/kg p.o. | 77.5 ± 1.7 | 7.8 ± 5.3 | 4.2 ± 2.1 | 94 ± 6.0a | |||
N.D., not determined.
↵ a Total recovery in dogs includes radioactivity in cage washes and debris.