TABLE 1

Mean (±S.D.) excretion of total radioactivity in urine and feces of mice, rats, rabbits, and dogs after single oral administration of 14C-RWJ-333369

Species
Dose
Radioactive Dose
No. of Animals
Excretion in
Total Excretiona
Urine
Feces
mg/kg MBq %
Male mice 50 0.030 12 86.63 ± 7.10 4.01 ± 1.47 98.12 ± 0.83
Female mice 50 0.020 12 60.09 ± 12.61 8.14 ± 6.00 90.45 ± 6.45b
Male rats 30 0.360 5 89.11 ± 3.79 9.77 ± 3.02 100.28 ± 0.73
Female rats 30 0.310 5 88.95 ± 5.36 9.09 ± 3.15 100.25 ± 2.48
Female rabbits 100 (200)c 5.54 (10.52)c 2 (1)c 97.79 ± 8.13 7.69 ± 2.60 106.11 ± 8.18
Male dogs
20
12.390
4
89.09 ± 3.25
7.37 ± 2.44
98.05 ± 3.45

  • ↵ a Including recovery from cage washings/debris.

  • ↵ b Significant amount recovered in cage washings/debris.

  • ↵ c One of the three female rabbits was dosed at 200 mg/kg and the values are given in parentheses.