Parameter | Mice (50 mg/kg)a | Rats (30 mg/kg)a | Female Rabbitsb | Male Dogsc (20 mg/kg) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Male | Female | Male | Female | (100 mg/kg) | (200 mg/kg) | |||||
Cmax (μg-Eq/ml) | 25.3 | 20.2 | 15.6 | 15.6 | 83.4 | 97.8 | 24.6 (1.75) | |||
Tmax (h) | 1.0 | 1.0 | 3.0 | 3.0 | 1.5 | 2.0 | 1.8 (0.50) | |||
t (h) | 3.7 | 4.1 | 6.6 | 5.6 | 14.6 | 15.8 | 44.9 (38.0) | |||
AUC0-t (μg-Eq · h/ml) | 95.8 | 93.6 | 174.8 | 177.5 | 654.7 | 1119.9 | 215.0 (246.2) | |||
AUC0-inf (μg-Eq · h/ml) | 97.3 | 95.6 | 192.0 | 188.0 | 663.2 | 1133.6 | 222.1 (285.4) |