IC50 values for drugs inhibiting AZT glucuronidation in the liver microsomes and hepatocytes of rats
The data represent the mean ± computer-calculated S.E.
Drug | IC50 | ||
|---|---|---|---|
| Liver Microsomes | Hepatocytes | ||
| μM | |||
| Diclofenac | 40 ± 1.8 | 58 ± 2.2 | |
| Diflunisal | 34 ± 7.1 | 37 ± 2.2 | |
| Fluconazole | 1791 ± 226 | N.D. | |
| Indomethacin | 103 ± 3.9 | 88 ± 16 | |
| Ketoprofen | 276 ± 7.7 | 361 ± 34 | |
| Mefenamic acid | 37 ± 0.9 | N.D. | |
| Naproxen | 332 ± 9.5 | 486 ± 52 | |
| Niflumic acid | 102 ± 5.8 | N.D. | |
| Valproic acid | 538 ± 35 | 281 ± 52 | |
N.D., not determined.