Parameters of reversible inhibition of CYP3A in HLMs by MA and MD
Results from this study are estimates (standard error) obtained using SAAM II software.
Findings from This Study | Literature Report | |||||
|---|---|---|---|---|---|---|
| Ki
a
| Type | Ki | Type | |||
| μM | μM | |||||
| MA | 2.7 (0.2) | Competitive | 2.2,2.5b | Competitive | ||
| MD | 0.2 (0.0) | Competitive | 0.07,0.1b | Competitive | ||
↵ a Results are estimates (standard error). Compounds were coincubated with midazolam (1.25-10 μM) for 1 min after NADPH was added.
↵ b Determined from two individuals (Sutton et al., 1997).