TABLE 4

Lack of time-dependent CYP3A inactivation by MD

MD	HLM Protein Binding^a (Percentage Free)	Percentage of MD Remaining^b	Percentage of CYP3A Activities^b
0.4 μM	88 (5)	N.D.	N.D.
1 μM	N.D.	109 (7)	96 (5)
2 μM	N.D.	101 (6)	103 (9)
4 μM	83 (5)	111 (13)	106 (5)

N.D., not determined.
↵ a Calculated according to eq.1. Values are mean (S.D.), n = 4 incubations at 0.2 mg/ml HLMs.
↵ b Calculated as the percentage remaining at 12 min tested in the inactivation experiments. Values are mean (S.D.), n = 3 incubations.