No. | IUPAC Name | Structurea | Caco-2 Efflux (B→A/A→B Ratio) | Caco2 Efflux with MK571 Inhibition (B→A/A→B Ratio) |
---|---|---|---|---|
1 | 2-Chloro-4′-hydroxybiphenyl | N.D. | N.A. | |
2 | 4′-Hydroxybiphenyl | 1.32 | N.A. | |
3 | 2-Fluoro-4′-hydroxybiphenyl | 1.35 | N.A. | |
4 | 2-Chloro-3′-fluoro-4′-hydroxybiphenyl | 0.83 | N.A. | |
5 | 2-Fluoro-4′-hydroxy-3′-methoxybiphenyl | 0.49 | N.A. | |
6 | 2-Fluoro-4′-hydroxy-3′,5′-dimethylbiphenyl | 1.64 | N.A. | |
7 | 4′-Hydroxy-3′-methoxybiphenyl | 0.80 | N.A. | |
8 | 3′-Fluoro-4′-hydroxybiphenyl | 1.09 | N.A. | |
9 | 4′-Hydroxy-3′,5′-dimethylbiphenyl | 0.49 | N.A. | |
10 | 2-Fluoro-4′-methoxy-3′-methylbiphenyl | 0.49 | N.A. | |
11 | 2-Fluoro-4′-hydroxy-3′-methylbiphenyl | N.D. | N.A. | |
12 | 3′,4′-Dihydroxybiphenyl | N.D. | N.A. | |
13 | 3′-Fluoro-2,4′-dihydroxybiphenyl | N.D. | N.A. | |
14 | 2-Ethoxy-3′-fluoro-4′-hydroxybiphenyl | 1.08 | N.A. | |
15 | 4′-Hydroxy-2,3′,5′-trimethylbiphenyl | 8.68 | 1.82 | |
16 | 3′-Fluoro-4′-hydroxy-2-methylbiphenyl |
| 10.14 | 2.52 |
17 | 4′-Hydroxy-2′-methylbiphenyl | 25.80 | 3.10 | |
18 | 4′-Hydroxy-2-methylbiphenyl | 13.85 | 2.55 | |
19 | 3′-Bromo-4′-hydroxy-2,5′-dimethylbiphenyl | 2.74 | 1.41 | |
20 | 4′-Hydroxy-3′-methoxy-2-methylbiphenyl | 50.34 | 2.83 | |
21 | 2′,6′-Difluoro-4′-hydroxy-2-methylbiphenyl | 34.13 | 3.32 | |
22 | 4′-Methoxy-2,3′-dimethylbiphenyl | 12.69 | 2.06 | |
23 | 2′,6′-Difluoro-4′-methoxy-2-methylbiphenyl | 16.68 | 6.23 | |
24 | 4′-Hydroxy-2′-methyl-2-(trifluoromethyl) biphenyl | 33.50 | 2.78 | |
25 | 4′-Hydroxy-2,2′,3′-trimethylbiphenyl | 17.06 | 1.37 | |
26 | 4′-Hydroxy-2,2′-dimethylbiphenyl |
| 26.02 | 2.53 |
N.D., not detected; N.A., not applied.