fu,inc | |||||||||
---|---|---|---|---|---|---|---|---|---|
Drug | Hepatocytes | ||||||||
106 cells/ml | 3.5a × 106 cells/ml | Microsomes (1 mg protein/ml) | |||||||
At Kp,maxb | At Kp,minc | At Kp,maxb | At Kp,minc | ||||||
Dextromethorphan | 0.80 | 0.93 | 0.57 | 0.82 | 0.98 | ||||
Quinine | 0.58 | 0.84 | 0.32 | 0.65 | 0.36 | ||||
Propranolol | 0.45 | 0.74 | 0.21 | 0.49 | 0.60 | ||||
Imipramine | 0.36 | 0.57 | 0.16 | 0.31 | 0.45 | ||||
Fluvoxamine | 0.25 | 0.54 | 0.10 | 0.28 | 0.27 | ||||
Fluoxetine | 0.09 | 0.26 | 0.03 | 0.10 | 0.09 |