Uptake ratios of E3S, E17βG, and DHEAS into OATP-expressing CHO cells
Substratea | Transporter | Uptake Rate OATP | Uptake Rate Wild-Type | Ratiob | |
|---|---|---|---|---|---|
| pmol/min · μg | |||||
| DHEAS | OATP1B3 | 1.158 | 0.272 | 4.3 (7.0) | |
| E17βG | OATP1B1 | 0.417 | 0.097 | 4.3 (6.2) | |
| E3S | OATP2B1 | 0.334 | 0.205 | 1.7 (2.3) | |
| Warfarinc | OATP1B3 | 0.116 | 0.135 | 0.9 | |
↵ a Determined at substrate concentrations of 10 μM).
↵ b Literature values in parentheses (Kullak-Ublick et al., 2001).
↵ c Negative control.