Enzyme | Km | Vmax | Vmax/Km | ||
---|---|---|---|---|---|
μM | pmol/min/mg | μl/min/mg | |||
HLM | 85.9 ± 6.9 | 133.4 ± 9.8 | 1.6 ± 0.0 | ||
HJM | 24.2 ± 4.1 | 184.6 ± 7.0 | 7.8 ± 1.0 | ||
HKM | 53.3 ± 5.4 | 22.6 ± 1.8 |
|
| 0.4 ± 0.0 |
Km | Vmax | Corrected Vmax | Ksi | Corrected Vmax/Km | |
---|---|---|---|---|---|
μM | pmol/min/mg | pmol/min/unit | μM | μl/min/unit | |
UGT1A1 | 104.9 ± 6.6 | 75.7 ± 0.7 | 75.7 ± 0.7 | 0.7 ± 0.1 | |
UGT1A3 | 33.2 ± 2.2 | 40.8 ± 2.4 | 204.0 ± 11.9 | 83.5 ± 14.3 | 6.2 ± 0.1 |
UGT1A7 | 38.1 ± 2.5 | 8.2 ± 0.3 | 13.7 ± 0.4 | 0.4 ± 0.0 | |
UGT1A8 | 45.4 ± 8.4 | 239.9 ± 38.2 | 299.9 ± 47.8 | 56.4 ± 22.5 | 6.6 ± 0.2 |
UGT1A9 | 24.1 ± 1.2 | 7.1 ± 0.9 | 10.4 ± 1.4 | 0.4 ± 0.0 | |
UGT1A10 | 96.3 ± 27.3 | 146.7 ± 26.3 | 349.4 ± 62.6 | 9.0 ± 1.5 | 3.7 ± 0.4 |
HLM, human liver microsomes; HJM, human jejunum microsomes; HKM, human kidney microsomes
Data are mean ± S.D. of three independent experiments.