TABLE 2

Individual pharmacokinetic parameters of raltegravir and radioactivity after administration of a single oral dose of [¹⁴C]raltegravir to healthy volunteers

Subject	Raltegravir					Radioactivity
Subject		AUC_{0-t h}^a	C_max	T_max	AUC_{0-t h}	C_max	T_max	AUC	C_max
	μM · h	μM	h	μM Eq · h	μM Eq	h
1	9.45	3.39	1.0	11.41	3.96	1.0	0.83	0.86
2	4.04	1.92	1.0	7.33	2.80	1.0	0.55	0.69
3	15.69	4.86	1.0	19.33	5.70	1.0	0.81	0.85
4	7.95	4.11	1.0	12.10	5.58	1.0	0.66	0.74
5	9.05	5.51	0.5	13.01	6.60	0.5	0.70	0.83
6	16.76	5.53	1.0	23.34	6.99	1.0	0.72	0.79
7	14.21	7.46	0.5	19.14	8.26	0.5	0.74	0.90
8	13.09	6.77	1.0	22.45	9.54	1.0	0.58	0.71
Mean	11.28	4.94	0.9	16.01	6.18	0.9	0.70	0.80
S.D.	4.36	1.80	0.2	5.82	2.18	0.2	0.10	0.08

↵ a t represents the last time point at which concentrations were above the limit of quantitation (20-24 h for raltegravir, 12-20 h for radioactivity).