TABLE 2

Pharmacokinetic parameters for nifedipine clearance

Blood nifedipine levels (from Fig. 2) were used to calculate pharmacokinetic parameters, including AUC, Tmax, Cmax, and t½. Values presented are means ± S.D. (n = 5-6 for each strain). Student's t test was used for statistical analysis of differences between B6 and CL strains.

Strain
Treatment Route
Tmax
Cmax
t½
AUC0-24 h
h nmol/ml h nmol/h/ml
B6 p.o. 0.7 ± 0.3 10.3 ± 1.4 1.9 ± 1.0 36.7 ± 20.3
CL p.o. 0.9 ± 0.2 12.7 ± 1.7a 13.3 ± 4.7b 147 ± 20b
B6 i.p. 0.5 ± 0.0 15.0 ± 3.1 1.3 ± 0.3 28.6 ± 4.2
CL
i.p.
0.7 ± 0.3
19.4 ± 2.8a
1.5 ± 0.5
52.3 ± 14.6b

  • ↵ a p < 0.05, compared with similarly treated B6 mice.

  • ↵ b p < 0.01, compared with similarly treated B6 mice.