TABLE 3

Pharmacokinetic parameters for nifedipine clearance in WT, LCN, and CL-LCN mice

Blood nifedipine levels (from Fig. 3) were used to calculate pharmacokinetic parameters, including AUC, Tmax, Cmax, and t½. Values presented are means ± S.D. (n = 5-6 for each strain). Student's t test was used for statistical analysis of differences between the WT and LCN or between LCN and CL-LCN strains.


Strain

Treatment Route

Tmax

Cmax

t½

AUC0-24 h
h nmol/ml h nmol/h/ml
WT p.o. 0.5 ± 0.0 5.8 ± 0.5 2.3 ± 0.9 23.6 ± 7.2
LCN p.o. 3.4 ± 1.3 12.7 ± 2.9a 8.5 ± 4.4b 163 ± 40a
CL-LCN p.o. 6.0 ± 0.0 22.4 ± 2.7c 11.0 ± 3.3 360 ± 40c
WT i.p. 0.6 ± 0.2 7.8 ± 0.9 0.6 ± 0.3 9.1 ± 2.0
LCN i.p. 1.7 ± 0.5 14.9 ± 0.8a 5.8 ± 1.3a 153 ± 11a
CL-LCN
i.p.
2.8 ± 1.8
16.3 ± 2.9
11.3 ± 5.3
241 ± 51c
  • a p < 0.01, compared with WT.

  • b p < 0.05, compared with WT.

  • c p < 0.01, compared with LCN.